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Target
Carbonic anhydrase 2
Ligand
BDBM542990
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
>10000±n/a nM
Citation
 Kleymann, G; Gege, C Enantiomers of substituted thiazoles as antiviral compounds US Patent  US11278534 Publication Date 3/22/2022 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM542990
Synonyms:
(+)-N-Methyl-N-(4-methyl-5-(S-methylsulfonimidoyl)thiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide | US11278534, Example 7c(+)
Type:
Small organic molecule
Emp. Form.:
C19H20N4O2S2
Mol. Mass.:
400.518
SMILES:
CN(C(=O)Cc1ccc(cc1)-c1ccccn1)c1nc(C)c(s1)[S@](C)(=N)=O |r|
Structure:
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