Reaction Details Report a problem with these data
Target
5'-AMP-activated protein kinase catalytic subunit alpha-1
Ligand
BDBM543471
Substrate
n/a
Meas. Tech.
In Vitro pAMPK1 Kinase Activation Assay
EC50
0.970±n/a nM
Citation
 Sebhat, I; He, S AMPK activators US Patent  US11279702 Publication Date 3/22/2022 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-1
Synonyms:
AAPK1_HUMAN | ACACA kinase | AMP-activated protein kinase alpha-1/beta-2/gamma-2 | AMP-activated protein kinase, alpha-1 subunit | AMPK subunit alpha-1 | AMPK-alpha1 | AMPK1 | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA1 | Tau-protein kinase PRKAA1
Type:
Protein
Mol. Mass.:
64023.62
Organism:
Homo sapiens (Human)
Description:
Q13131
Residue:
559
Sequence:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
  
Inhibitor
Name:
BDBM543471
Synonyms:
(((6-chloro-5-(2'-hydroxy-[1,1'-biphenyl]-4- yl)-1H-imidazo[4,5-b]pyridin-2- yl)thio)methyl)(methyl)phosphinic acid | US11279702, Compound 2
Type:
Small organic molecule
Emp. Form.:
C20H17ClN3O3PS
Mol. Mass.:
445.859
SMILES:
CP(O)(=O)CSc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccccc1O
Structure:
Search PDB for entries with ligand similarity: