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Target
5'-AMP-activated protein kinase catalytic subunit alpha-1
Ligand
BDBM543475
Substrate
n/a
Meas. Tech.
In Vitro pAMPK1 Kinase Activation Assay
EC50
43.0±n/a nM
Citation
 Sebhat, I; He, S AMPK activators US Patent  US11279702 Publication Date 3/22/2022 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-1
Synonyms:
AAPK1_HUMAN | ACACA kinase | AMP-activated protein kinase alpha-1/beta-2/gamma-2 | AMP-activated protein kinase, alpha-1 subunit | AMPK subunit alpha-1 | AMPK-alpha1 | AMPK1 | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA1 | Tau-protein kinase PRKAA1
Type:
Protein
Mol. Mass.:
64023.62
Organism:
Homo sapiens (Human)
Description:
Q13131
Residue:
559
Sequence:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
  
Inhibitor
Name:
BDBM543475
Synonyms:
(S)-2-((6-chloro-5-(4-(3-hydroxypyrrolidin- 1-yl)phenyl)-1H-imidazo[4,5-b]pyridin-2- yl)thio)acetic acid | US11279702, Compound 7
Type:
Small organic molecule
Emp. Form.:
C18H17ClN4O3S
Mol. Mass.:
404.871
SMILES:
O[C@H]1CCN(C1)c1ccc(cc1)-c1nc2nc(SCC(O)=O)[nH]c2cc1Cl |r|
Structure:
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