Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM386205
Substrate
n/a
Meas. Tech.
Measurement of Orexin Type 2 Receptor Agonist Activity
EC50
0.310±n/a nM
Citation
 Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T; Tokunaga, N; Hirozane, M Substituted piperidine compound and use thereof US Patent  US11292766 Publication Date 4/5/2022 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM386205
Synonyms:
US10287305, Example 179 | US10508083, Example 179 | US11292766, Example 179 | cis-N-(cyanomethyl)-3- ((methylsulfonyl)amino)-2-(((cis-4- phenylcyclohexyl)oxy)methyl)- piperidine-1-carboxamide
Type:
Small organic molecule
Emp. Form.:
C22H32N4O4S
Mol. Mass.:
448.579
SMILES:
CS(=O)(=O)N[C@H]1CCCN([C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1)C(=O)NCC#N |r,wU:16.20,13.13,10.11,5.4,(6.67,.38,;5.33,1.15,;4.56,2.49,;6.1,2.49,;4,.38,;4,-1.15,;5.33,-1.93,;5.33,-3.47,;4,-4.23,;2.67,-3.47,;2.67,-1.93,;1.33,-1.15,;1.33,.38,;,1.15,;-1.33,.39,;-2.67,1.15,;-2.67,2.69,;-1.33,3.47,;,2.69,;-4,3.47,;-4,5,;-5.33,5.78,;-6.67,5,;-6.67,3.47,;-5.33,2.69,;1.33,-4.23,;1.33,-5.78,;,-3.47,;-1.33,-4.23,;-2.67,-3.47,;-4,-2.69,)|
Structure:
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