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Target
Bromodomain-containing protein 4 [44-167]
Ligand
BDBM550496
Substrate
n/a
Meas. Tech.
ATPLITE assay
IC50
48.0±n/a nM
Citation
 Bradner, JE; Qi, J; Tanaka, M; Buckley, D Cyano thienotriazolodiazepines and uses thereof US Patent  US11306105 Publication Date 4/19/2022 
Target
Name:
Bromodomain-containing protein 4 [44-167]
Synonyms:
BRD4 | BRD4 bromodomain 1 | BRD4_HUMAN | Brd4-1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14738.39
Organism:
Homo sapiens (Human)
Description:
O60885[44-167]
Residue:
124
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
  
Inhibitor
Name:
BDBM550496
Synonyms:
US11306105, Compound 200
Type:
Small organic molecule
Emp. Form.:
C21H18ClN5O2S
Mol. Mass.:
439.918
SMILES:
COC(=O)C[C@@H]1N=C(c2c(C)c(CC#N)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |r,c:6|
Structure:
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