Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein [1-379,R71H,G230A,H232R,R293Q]
Ligand
BDBM550753
Substrate
n/a
Meas. Tech.
H-cGAMP Filtration Binding Assay (HAQ STING)
IC50
828±n/a nM
Citation
 Altman, MD; Childers, ML; Jewell, JP; Lesburg, CA; Siu, T Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors US Patent  US11311528 Publication Date 4/26/2022 
Target
Name:
Stimulator of interferon genes protein [1-379,R71H,G230A,H232R,R293Q]
Synonyms:
ERIS | HAQ STING(1-379) (R71H, G230A, H232R, R293Q) | MITA | STING | STING1 | STING_HUMAN | Stimulator of interferon genes protein (1-379) (R71H, G230A, H232R, R293Q) | Stimulator of interferon genes protein [R71H,G230A,H232R,R293Q] | TMEM173
Type:
Protein
Mol. Mass.:
42180.60
Organism:
Human
Description:
HAQ STING(1-379) (R71H, G230A, H232R, R293Q)
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELHHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTADRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCQTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM550753
Synonyms:
(3S,4S) and (3R,4R)-2-(4-cyclopropyl-3- fluorophenyl)-3-(2,3-dihydro-1,4- benzodioxin-6-yl)-1-oxo-1,2,3,4- tetrahydroisoquinoline-4-carboxylic acid | US11311528, Ex. 1-43
Type:
Small organic molecule
Emp. Form.:
C27H22FNO5
Mol. Mass.:
459.4657
SMILES:
OC(=O)[C@@H]1[C@H](N(C(=O)c2ccccc12)c1ccc(C2CC2)c(F)c1)c1ccc2OCCOc2c1 |r|
Structure:
Search PDB for entries with ligand similarity: