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Target
Cathepsin K
Ligand
BDBM123099
Substrate
n/a
Meas. Tech.
Determination of Cathepsin K Proteolytic Catalytic Activity
Ki
4.00±n/a nM
Citation
 Oden, LS; Nilsson, M; Kahnberg, P; Samuelsson, B; Grabowska, U Protease inhibitors US Patent  US11312693 Publication Date 4/26/2022 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM123099
Synonyms:
US10723709, Example 3 | US11312693, Example 3 | US8735395, 3
Type:
Small organic molecule
Emp. Form.:
C29H34FN5O4S
Mol. Mass.:
567.675
SMILES:
CC(C)C[C@H](NC(=O)c1ccc(-c2csc(n2)N2CCN(C)CC2)c(F)c1)C(=O)N1C[C@@H](C#C)[C@H]2OCC(=O)[C@@H]12 |r|
Structure:
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