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Target
Voltage-dependent calcium channel gamma-8 subunit
Ligand
BDBM551030
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
IC50
0.020±n/a nM
Citation
 Ameriks, MK; Berry, CG; Chen, G; Ravula, S; Savall, BM; Swanson, DM; Wu, D; Zhang, W Azabenzimidazoles and their use as AMPA receptor modulators US Patent  US11312712 Publication Date 4/26/2022 
Target
Name:
Voltage-dependent calcium channel gamma-8 subunit
Synonyms:
CACNG6 | CACNG8 | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43326.96
Organism:
Homo sapiens (Human)
Description:
Q8WXS5
Residue:
425
Sequence:
MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV
  
Inhibitor
Name:
BDBM551030
Synonyms:
3-(7-Bromo-1H-indazol-5-yl)-2-cyclobutyl-5-(trifluoromethyl)imidazo[4,5- | US11312712, Example 138
Type:
Small organic molecule
Emp. Form.:
C18H13BrF3N5
Mol. Mass.:
436.229
SMILES:
FC(F)(F)c1ccc2nc(C3CCC3)n(-c3cc(Br)c4[nH]ncc4c3)c2n1
Structure:
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