Reaction Details Report a problem with these data
Target
Voltage-dependent calcium channel gamma-8 subunit
Ligand
BDBM551136
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
IC50
0.032±n/a nM
Citation
 Ameriks, MK; Berry, CG; Chen, G; Ravula, S; Savall, BM; Swanson, DM; Wu, D; Zhang, W Azabenzimidazoles and their use as AMPA receptor modulators US Patent  US11312712 Publication Date 4/26/2022 
Target
Name:
Voltage-dependent calcium channel gamma-8 subunit
Synonyms:
CACNG6 | CACNG8 | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43326.96
Organism:
Homo sapiens (Human)
Description:
Q8WXS5
Residue:
425
Sequence:
MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV
  
Inhibitor
Name:
BDBM551136
Synonyms:
3-(7-Chloro-1H-indazol-5-yl)-2-(3-fluorocyclobutyl)-5- | US11312712, Example 250
Type:
Small organic molecule
Emp. Form.:
C18H12ClF4N5
Mol. Mass.:
409.768
SMILES:
F[C@H]1C[C@@H](C1)c1nc2ccc(nc2n1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F |r,wU:3.5,wD:1.0,(6.48,2.77,;4.94,2.77,;3.85,3.86,;2.76,2.77,;3.85,1.68,;1.22,2.77,;.32,4.02,;-1.15,3.54,;-2.48,4.31,;-3.81,3.54,;-3.81,2,;-2.48,1.23,;-1.15,2,;.32,1.52,;.72,.04,;-.37,-1.05,;.03,-2.54,;-1.06,-3.63,;1.51,-2.94,;2.21,-4.31,;3.73,-4.07,;3.97,-2.55,;2.6,-1.85,;2.2,-.36,;-5.15,1.23,;-6.48,2,;-5.15,2.77,;-5.15,-.31,)|
Structure:
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