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Target
Voltage-dependent calcium channel gamma-8 subunit
Ligand
BDBM551153
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
IC50
0.020±n/a nM
Citation
 Ameriks, MK; Berry, CG; Chen, G; Ravula, S; Savall, BM; Swanson, DM; Wu, D; Zhang, W Azabenzimidazoles and their use as AMPA receptor modulators US Patent  US11312712 Publication Date 4/26/2022 
Target
Name:
Voltage-dependent calcium channel gamma-8 subunit
Synonyms:
CACNG6 | CACNG8 | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43326.96
Organism:
Homo sapiens (Human)
Description:
Q8WXS5
Residue:
425
Sequence:
MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV
  
Inhibitor
Name:
BDBM551153
Synonyms:
3-(7-Chloro-1H-indazol-5-yl)-2,5-bis(trifluoromethyl)imidazo[4,5-b]pyridine; | US11312712, Example 270
Type:
Small organic molecule
Emp. Form.:
C15H6ClF6N5
Mol. Mass.:
405.685
SMILES:
FC(F)(F)c1nc2ccc(nc2n1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
Structure:
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