Reaction Details Report a problem with these data
Target
Voltage-dependent calcium channel gamma-8 subunit
Ligand
BDBM551239
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
IC50
0.032±n/a nM
Citation
 Ameriks, MK; Berry, CG; Chen, G; Ravula, S; Savall, BM; Swanson, DM; Wu, D; Zhang, W Azabenzimidazoles and their use as AMPA receptor modulators US Patent  US11312712 Publication Date 4/26/2022 
Target
Name:
Voltage-dependent calcium channel gamma-8 subunit
Synonyms:
CACNG6 | CACNG8 | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43326.96
Organism:
Homo sapiens (Human)
Description:
Q8WXS5
Residue:
425
Sequence:
MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV
  
Inhibitor
Name:
BDBM551239
Synonyms:
7-Chloro-5-(2-isopropylpyrrolo[2,3-b]pyridin-1-yl)indolin-2-one; | US11312712, Example 357
Type:
Small organic molecule
Emp. Form.:
C18H16ClN3O
Mol. Mass.:
325.792
SMILES:
CC(C)c1cc2cccnc2n1-c1cc2CC(=O)Nc2c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: