Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [44-167]
Ligand
BDBM552031
Substrate
n/a
Meas. Tech.
BRD4 Biochemical Activity Test
IC50
49.0±n/a nM
Citation
 Shen, C; Wu, C; Liu, Y; Gong, Z; Li, J; Chen, S Thienodiazepine derivatives and application thereof US Patent  US11312726 Publication Date 4/26/2022 
Target
Name:
Bromodomain-containing protein 4 [44-167]
Synonyms:
BRD4 | BRD4 bromodomain 1 | BRD4_HUMAN | Brd4-1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14738.39
Organism:
Homo sapiens (Human)
Description:
O60885[44-167]
Residue:
124
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
  
Inhibitor
Name:
BDBM552031
Synonyms:
US11312726, Compound 2
Type:
Small organic molecule
Emp. Form.:
C27H23ClN6O2S
Mol. Mass.:
531.029
SMILES:
Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)Nc1ccc3C(=O)NCc3c1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8|
Structure:
Search PDB for entries with ligand similarity: