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Target
Bromodomain-containing protein 4 [44-167]
Ligand
BDBM552046
Substrate
n/a
Meas. Tech.
BRD4 Biochemical Activity Test
IC50
24.0±n/a nM
Citation
 Shen, C; Wu, C; Liu, Y; Gong, Z; Li, J; Chen, S Thienodiazepine derivatives and application thereof US Patent  US11312726 Publication Date 4/26/2022 
Target
Name:
Bromodomain-containing protein 4 [44-167]
Synonyms:
BRD4 | BRD4 bromodomain 1 | BRD4_HUMAN | Brd4-1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14738.39
Organism:
Homo sapiens (Human)
Description:
O60885[44-167]
Residue:
124
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
  
Inhibitor
Name:
BDBM552046
Synonyms:
US11312726, Compound 17
Type:
Small organic molecule
Emp. Form.:
C29H27ClN6O2S
Mol. Mass.:
559.082
SMILES:
CC(=O)N1Cc2ccc(NC(=O)C[C@@H]3N=C(c4c(C)c(C)sc4-n4c(C)nnc34)c3ccc(Cl)cc3)cc2C1 |r,c:14|
Structure:
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