Reaction Details Report a problem with these data
Target
Polymerase basic protein 2
Ligand
BDBM552230
Substrate
n/a
Meas. Tech.
EN PA FRET Inhibition Assay
IC50
6.00±n/a nM
Citation
 Hendricks, RT; Stoycheva, AD; Bonfanti, J; Raboisson, PJ; Fortin, JM; Mercey, GJ Macrocyclic flu endonuclease inhibitors US Patent  US11312727 Publication Date 4/26/2022 
Target
Name:
Polymerase basic protein 2
Synonyms:
B4URF7_I33A0 | PB2 | RNA-directed RNA polymerase subunit P3
Type:
Protein
Mol. Mass.:
85824.43
Organism:
Influenza A virus (strain A/WS/1933 H1N1)
Description:
B4URF7
Residue:
759
Sequence:
MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKIYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTTTKEKKEELQGCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEARNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGVRMVNILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIESIDNVMGMIGILPDMTPSTEMSMRGVRISKMGVDEYSSAEKIVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAVRGQYSGFVRTLFQQMRDVLGTFDTAQIIKLLPFAAAPPKQSGMQFSSLTINVRGSGMRILVRGNSPVFNYNKTTKRLTVLGKDAGPLTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRNSSILTDSQTATKRIRMAIN
  
Inhibitor
Name:
BDBM552230
Synonyms:
(23b*R, Z)-16,17-difluoro-6-hydroxy-10,13,18,23b-tetrahydro-9H-1,8-methano[1]benzothiepino[5,4,3-1m]pyrido[2,1-i][1,7,10,11]benzoxatriazacyclotetradecine-5,7-dione (Compound 88A) | US11312727, Compound 88D
Type:
Small organic molecule
Emp. Form.:
C26H21F2N3O4S
Mol. Mass.:
509.524
SMILES:
Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C\CC3)c45)n2ccc1=O |r,t:27|
Structure:
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