Reaction Details Report a problem with these data
Target
Polymerase basic protein 2
Ligand
BDBM552276
Substrate
n/a
Meas. Tech.
Influenza Antiviral Assay
EC50
1.000±n/a nM
Citation
 Hendricks, RT; Stoycheva, AD; Bonfanti, J; Raboisson, PJ; Fortin, JM; Mercey, GJ Macrocyclic flu endonuclease inhibitors US Patent  US11312727 Publication Date 4/26/2022 
Target
Name:
Polymerase basic protein 2
Synonyms:
B4URF7_I33A0 | PB2 | RNA-directed RNA polymerase subunit P3
Type:
Protein
Mol. Mass.:
85824.43
Organism:
Influenza A virus (strain A/WS/1933 H1N1)
Description:
B4URF7
Residue:
759
Sequence:
MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKIYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTTTKEKKEELQGCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEARNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGVRMVNILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIESIDNVMGMIGILPDMTPSTEMSMRGVRISKMGVDEYSSAEKIVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAVRGQYSGFVRTLFQQMRDVLGTFDTAQIIKLLPFAAAPPKQSGMQFSSLTINVRGSGMRILVRGNSPVFNYNKTTKRLTVLGKDAGPLTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRNSSILTDSQTATKRIRMAIN
  
Inhibitor
Name:
BDBM552276
Synonyms:
(17a′*R,*E)-12′-hydroxy-2′,17a′-dihydro-6′H-spiro[cyclopropane-1,9′-[3,4](epiprop[1]en[1]yl[3]ylidene)[10,17]methanobenzo[6,7]thiepino[4,5-c]pyrido[1,2-f][1]oxa[5,6,9]triazacyclotridecine]-11′,13′-dione (Compound 107A) | US11312727, Compound 107B
Type:
Small organic molecule
Emp. Form.:
C27H23N3O4S
Mol. Mass.:
485.554
SMILES:
Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5cccc(OC\C=C\C33CC3)c45)n2ccc1=O |r,t:25|
Structure:
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