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Target
Polymerase basic protein 2
Ligand
BDBM552404
Substrate
n/a
Meas. Tech.
Influenza Antiviral Assay
EC50
0.230±n/a nM
Citation
 Hendricks, RT; Stoycheva, AD; Bonfanti, J; Raboisson, PJ; Fortin, JM; Mercey, GJ Macrocyclic flu endonuclease inhibitors US Patent  US11312727 Publication Date 4/26/2022 
Target
Name:
Polymerase basic protein 2
Synonyms:
B4URF7_I33A0 | PB2 | RNA-directed RNA polymerase subunit P3
Type:
Protein
Mol. Mass.:
85824.43
Organism:
Influenza A virus (strain A/WS/1933 H1N1)
Description:
B4URF7
Residue:
759
Sequence:
MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKIYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTTTKEKKEELQGCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEARNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGVRMVNILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIESIDNVMGMIGILPDMTPSTEMSMRGVRISKMGVDEYSSAEKIVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAVRGQYSGFVRTLFQQMRDVLGTFDTAQIIKLLPFAAAPPKQSGMQFSSLTINVRGSGMRILVRGNSPVFNYNKTTKRLTVLGKDAGPLTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRNSSILTDSQTATKRIRMAIN
  
Inhibitor
Name:
BDBM552404
Synonyms:
US11312727, Compound 162B
Type:
Small organic molecule
Emp. Form.:
C26H21F2N3O4S
Mol. Mass.:
509.524
SMILES:
C[C@H]1\C=C\COc2cc(F)c(F)c3CSc4ccccc4[C@@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23 |r,t:2|
Structure:
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