Reaction Details Report a problem with these data
Target
Polymerase basic protein 2
Ligand
BDBM552439
Substrate
n/a
Meas. Tech.
Influenza Antiviral Assay
EC50
1.20±n/a nM
Citation
 Hendricks, RT; Stoycheva, AD; Bonfanti, J; Raboisson, PJ; Fortin, JM; Mercey, GJ Macrocyclic flu endonuclease inhibitors US Patent  US11312727 Publication Date 4/26/2022 
Target
Name:
Polymerase basic protein 2
Synonyms:
B4URF7_I33A0 | PB2 | RNA-directed RNA polymerase subunit P3
Type:
Protein
Mol. Mass.:
85824.43
Organism:
Influenza A virus (strain A/WS/1933 H1N1)
Description:
B4URF7
Residue:
759
Sequence:
MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKIYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTTTKEKKEELQGCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEARNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGVRMVNILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIESIDNVMGMIGILPDMTPSTEMSMRGVRISKMGVDEYSSAEKIVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAVRGQYSGFVRTLFQQMRDVLGTFDTAQIIKLLPFAAAPPKQSGMQFSSLTINVRGSGMRILVRGNSPVFNYNKTTKRLTVLGKDAGPLTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRNSSILTDSQTATKRIRMAIN
  
Inhibitor
Name:
BDBM552439
Synonyms:
(18′*R,*E)-3′,4′-difluoro-12′-hydroxy-18′-(o-tolyl)-6′H,18′H-spiro[cyclobutane-1,9′-[10,17]methanobenzo[b]pyrido[1,2-f][1]oxa[5,6,9]triazacyclotridecine]-11′,13′-dione (Compound 174A) | US11312727, Compound 174B
Type:
Small organic molecule
Emp. Form.:
C28H25F2N3O4
Mol. Mass.:
505.5126
SMILES:
Cc1ccccc1[C@@H]1N2CN(C(=O)c3c(O)c(=O)ccn23)C2(CCC2)\C=C\COc2c(F)c(F)ccc12 |r,t:29|
Structure:
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