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Target
Tyrosine-protein kinase JAK1 [837-1142]
Ligand
BDBM246870
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
<10±n/a nM
Citation
 Assad, A Combination therapy for treatment of hematological diseases US Patent  US11324749 Publication Date 5/10/2022 
Target
Name:
Tyrosine-protein kinase JAK1 [837-1142]
Synonyms:
JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:
n/a
Mol. Mass.:
35230.04
Organism:
Homo sapiens (Human)
Description:
P23458[837-1142]
Residue:
306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM246870
Synonyms:
US10053465, 9 | US10065963, Compound 9 | US10125150, Example 9 | US10336759, # 9 | US10479803, Example 9 | US10675284, Example 9 | US11084822, Example 9 | US11130767, # 9 | US11136326, Example 9 | US11285140, Example 85 | US11304949, Compound 3 | US11324749, Comp. No. 3 | US11406640, Comp. No. 3 | US11596632, Comp. No. 3 | US20240058343, Compound 3 | US9732097, Example 9 | US9999619, Example 86 | [3-[4-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1-yl]-1- (1-{[2- (trifluoromethyl) pyrimidin-4- yl]carbonyl} piperidin-4-yl) azetidin-3- yl]acetonitrile
Type:
Small organic molecule
Emp. Form.:
C25H23F3N10O
Mol. Mass.:
536.5117
SMILES:
FC(F)(F)c1nccc(n1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Structure:
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