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Target
GTP-binding protein Rheb
Ligand
BDBM554958
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
IC50
200000±n/a nM
Citation
 Mahoney, S; Molz, L; Narayan, S; Saiah, E Heteroaryl Rheb inhibitors and uses thereof US Patent  US11339144 Publication Date 5/24/2022 
Target
Name:
GTP-binding protein Rheb
Synonyms:
RHEB | RHEB2 | RHEB_HUMAN | Ras homolog enriched in brain
Type:
PROTEIN
Mol. Mass.:
20495.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108016
Residue:
184
Sequence:
MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM
  
Inhibitor
Name:
BDBM554958
Synonyms:
US11339144, Compound I-427
Type:
Small organic molecule
Emp. Form.:
C16H10ClN3O2
Mol. Mass.:
311.723
SMILES:
Clc1ccc2[nH]c(nc2c1Oc1ccccc1)-c1ncco1
Structure:
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