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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM556300
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
1.80±n/a nM
Citation
 Rai, R; Booth, R; Green, MJ PGDH inhibitors and methods of making and using US Patent  US11345702 Publication Date 5/31/2022 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM556300
Synonyms:
US11345702, Table 1.18 | US20230390274, Compound A-26
Type:
Small organic molecule
Emp. Form.:
C22H22ClN3O3
Mol. Mass.:
411.881
SMILES:
CCOC(=O)c1nc2cc(ccc2n1-c1cccc(Cl)c1)C(=O)N1CCCCC1 |$;;O;;;;;;;;;;;;;;;;;;;;;;;;;;$|
Structure:
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