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Target
Cyclin-dependent kinase 6
Ligand
BDBM556327
Substrate
n/a
Meas. Tech.
CDK6 Inhibition Assay
IC50
1.19±n/a nM
Citation
 Song, Y; Chen, X Substituted pyrimidines as CDK4/6 inhibitors US Patent  US11351170 Publication Date 6/7/2022 
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM556327
Synonyms:
(S)-(3-(dimethylamino)pyrrolidin-1-yl)(6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-ylamino)pyridin-3-yl)methanone | US11351170, Example 6
Type:
Small organic molecule
Emp. Form.:
C28H30F2N8O
Mol. Mass.:
532.5876
SMILES:
CN(C)[C@H]1CCN(C1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCC(C)(C)n4c3c2)nc1 |r|
Structure:
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