Reaction Details Report a problem with these data
Target
Epidermal growth factor receptor [1-770,'SVD',771-1210]
Ligand
BDBM557889
Substrate
n/a
Meas. Tech.
Cell Viability Assay and IC50 Estimation
IC50
>10000±n/a nM
Citation
 Heymach, J; Robichaux, J; Nilsson, M; Jones, P; Cross, J; Theroff, J Heterocyclic inhibitors of tyrosine kinase US Patent  US11365189 Publication Date 6/21/2022 
Target
Name:
Epidermal growth factor receptor [1-770,'SVD',771-1210]
Synonyms:
EGFR | EGFR_HUMAN | ERBB | ERBB1 | HER1 | egfr s768dupsvd
Type:
Enzyme Catalytic Domain
Mol. Mass.:
134579.87
Organism:
Homo sapiens (Human)
Description:
P00533[1-770,'SVD',771-1210]
Residue:
1213
Sequence:
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDSVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
  
Inhibitor
Name:
BDBM557889
Synonyms:
1-(4-((7-methoxy-4-((1- methyl-1H-indazol-7-yl)- amino)quinazolin-6-yl)- oxy)piperidin-1-yl)prop-2- en-1-one | US11365189, Ex. No. 26
Type:
Small organic molecule
Emp. Form.:
C25H26N6O3
Mol. Mass.:
458.5123
SMILES:
COc1cc2ncnc(Nc3cccc4cnn(C)c34)c2cc1OC1CCN(CC1)C(=O)C=C
Structure:
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