Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM189770
Substrate
n/a
Meas. Tech.
TBDTR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) Assay
Ki
<0.010±n/a nM
Citation
 Birtalan, E; Hoelig, P; Lindley, DJ; Sanzgiri, YD; Tong, P Melt-extruded solid dispersions containing an apoptosis-inducing agent US Patent  US11369599 Publication Date 6/28/2022 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM189770
Synonyms:
US11369599, Compound 341 | US9174982, 341
Type:
Small organic molecule
Emp. Form.:
C46H50Cl2N6O6S
Mol. Mass.:
885.897
SMILES:
CC1(O)CCC(COc2ncc(cc2Cl)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC4(CC4)CC3)c3ccc(Cl)cc3)CC2)CC1 |t:46,(2.84,-15.44,;4.2,-14.72,;2.84,-14,;4.97,-16.05,;6.51,-16.05,;7.28,-14.72,;8.82,-14.72,;9.59,-13.39,;11.13,-13.39,;11.9,-12.05,;13.44,-12.05,;14.21,-13.39,;13.44,-14.72,;11.9,-14.72,;11.13,-16.05,;15.75,-13.39,;15.75,-14.93,;15.75,-11.85,;17.29,-13.39,;18.06,-12.05,;19.6,-12.05,;17.29,-10.72,;15.75,-10.72,;14.98,-9.39,;15.75,-8.05,;17.29,-8.05,;18.06,-9.39,;19.6,-9.39,;20.37,-8.05,;19.6,-6.72,;20.37,-5.38,;21.91,-5.38,;22.94,-4.24,;24.34,-4.87,;24.18,-6.4,;22.68,-6.72,;21.91,-8.05,;14.98,-6.72,;13.44,-6.72,;12.67,-5.38,;13.44,-4.05,;12.67,-2.72,;11.13,-2.72,;10.36,-1.38,;8.82,-1.38,;8.05,-2.72,;6.71,-3.49,;6.71,-1.95,;8.82,-4.05,;10.36,-4.05,;11.13,-.05,;10.36,1.28,;11.13,2.62,;12.67,2.62,;13.44,3.95,;13.44,1.28,;12.67,-.05,;14.98,-4.05,;15.75,-5.38,;6.51,-13.39,;4.97,-13.39,)|
Structure:
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