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Target
Apoptosis regulator Bcl-2
Ligand
BDBM356786
Substrate
n/a
Meas. Tech.
TBDTR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) Assay
Ki
<0.010±n/a nM
Citation
 Birtalan, E; Hoelig, P; Lindley, DJ; Sanzgiri, YD; Tong, P Melt-extruded solid dispersions containing an apoptosis-inducing agent US Patent  US11369599 Publication Date 6/28/2022 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM356786
Synonyms:
4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2S)-4,4-difluoro-1-oxetan-3-ylpyrrolidin-2-yl]methoxy}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | US10213433, Compound 168 | US11369599, Compound 168 | US20240043404, Example 168
Type:
Small organic molecule
Emp. Form.:
C47H50ClF2N7O8S
Mol. Mass.:
946.457
SMILES:
CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(OC[C@@H]4CC(F)(F)CN4C4COC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:63|
Structure:
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