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Target
Aurora kinase A
Ligand
BDBM560635
Substrate
n/a
Meas. Tech.
Evaluation of Aurora a and Aurora B Inhibitory Effect Kinase Assay
IC50
3.10±n/a nM
Citation
 Cheng, D; Chen, M; Li, A; Li, H; Yang, G Heterocyclic compounds useful as aurora a selective inhibitors US Patent  US11384066 Publication Date 7/12/2022 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM560635
Synonyms:
(2R,4R)-4-((3-fluoro-6- ((5-methyl-1H-pyrazol-3- yl)amino)pyridin-2-yl) methyl)-2-methyl-1-(3- (trifluoromethyl)benzyl) piperidine-4-carboxylic acid | US11384066, Example 21
Type:
Small organic molecule
Emp. Form.:
C25H27F4N5O2
Mol. Mass.:
505.5078
SMILES:
C[C@@H]1C[C@@](Cc2nc(Nc3cc(C)[nH]n3)ccc2F)(CCN1Cc1cccc(c1)C(F)(F)F)C(O)=O
Structure:
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