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Target
Arginase-1
Ligand
BDBM290419
Substrate
n/a
Meas. Tech.
Inhibition of Arginase
IC50
125±n/a nM
Citation
 Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent  US11389464 Publication Date 7/19/2022 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM290419
Synonyms:
(3R,4S)-3-amino-4-(3-boronopropyl)-1-((7-(trifluoromethyl)- 1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)pyrrolidine-3-carboxylic acid | US10098902, Example 55 | US10603330, Example 55 | US11389464, Example 55
Type:
Small organic molecule
Emp. Form.:
C19H27BF3N3O4
Mol. Mass.:
429.242
SMILES:
N[C@]1(CN(CC2Cc3ccc(cc3CN2)C(F)(F)F)C[C@@H]1CCCB(O)O)C(O)=O |r|
Structure:
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