Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM561409
Substrate
n/a
Meas. Tech.
Adenosine A2B Receptor Cyclic AMP GS Assay
EC50
<10±n/a nM
Citation
 Huang, T; Wang, X Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors US Patent  US11390624 Publication Date 7/19/2022 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM561409
Synonyms:
3-(4-amino-2-((6-methylpyridin-2-yl)methyl)-7-(pyrimidin-4-yl)-2H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)benzonitrile | US11390624, Example 24
Type:
Small organic molecule
Emp. Form.:
C23H17N9
Mol. Mass.:
419.4414
SMILES:
Cc1cccc(Cn2nc3c(N)nc(-c4cccc(c4)C#N)c(-c4ccncn4)c3n2)n1
Structure:
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