Reaction Details Report a problem with these data
Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D7 [S54D]
Ligand
BDBM50049146
Substrate
n/a
Meas. Tech.
Kinetic Assay
IC50
>1000±n/a nM
Citation
 Gurney, ME; Hagen, TJ; Mo, X; Vellekoop, AS; Romero, DL; Campbell, R; Walker, JR; Zhu, L Heteroaryl inhibitors of PDE4 US Patent  US11401286 Publication Date 8/2/2022 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D7 [S54D]
Synonyms:
DPDE3 | PDE4D | PDE4D_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
84232.40
Organism:
Homo sapiens (Human)
Description:
Q08499-2[S54D]
Residue:
745
Sequence:
NTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESSGFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRREDFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
  
Inhibitor
Name:
BDBM50049146
Synonyms:
CHEMBL3315251 | US11401286, Example 36
Type:
Small organic molecule
Emp. Form.:
C20H17ClN4O2
Mol. Mass.:
380.828
SMILES:
OC(=O)Cc1ccc(Nc2nc(nc(n2)-c2cccc(Cl)c2)C2CC2)cc1
Structure:
Search PDB for entries with ligand similarity: