Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [44-167]
Ligand
BDBM562570
Substrate
n/a
Meas. Tech.
Acetyl-Histone Binding Assay
IC50
36.0±n/a nM
Citation
 Bradner, JE; Qi, J; Tanaka, M Acetamide thienotriazolodiazepines and uses thereof US Patent  US11406645 Publication Date 8/9/2022 
Target
Name:
Bromodomain-containing protein 4 [44-167]
Synonyms:
BRD4 | BRD4 bromodomain 1 | BRD4_HUMAN | Brd4-1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14738.39
Organism:
Homo sapiens (Human)
Description:
O60885[44-167]
Residue:
124
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
  
Inhibitor
Name:
BDBM562570
Synonyms:
US11406645, Compound 501
Type:
Small organic molecule
Emp. Form.:
C22H24ClN5O2S
Mol. Mass.:
457.976
SMILES:
C[C@H](O)CNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |r,c:9|
Structure:
Search PDB for entries with ligand similarity: