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Target
Bromodomain-containing protein 4 [44-167]
Ligand
BDBM562623
Substrate
n/a
Meas. Tech.
Acetyl-Histone Binding Assay
IC50
29.0±n/a nM
Citation
 Bradner, JE; Qi, J; Tanaka, M Acetamide thienotriazolodiazepines and uses thereof US Patent  US11406645 Publication Date 8/9/2022 
Target
Name:
Bromodomain-containing protein 4 [44-167]
Synonyms:
BRD4 | BRD4 bromodomain 1 | BRD4_HUMAN | Brd4-1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14738.39
Organism:
Homo sapiens (Human)
Description:
O60885[44-167]
Residue:
124
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
  
Inhibitor
Name:
BDBM562623
Synonyms:
US11406645, Compound 505
Type:
Small organic molecule
Emp. Form.:
C22H22ClF2N5OS
Mol. Mass.:
477.958
SMILES:
Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCC(F)F)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8|
Structure:
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