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Target
Mitogen-activated protein kinase 14
Ligand
BDBM563641
Substrate
n/a
Meas. Tech.
MAPK13 and MAPK14 enzyme assays
IC50
11.0±n/a nM
Citation
 Holtzman, MJ; Romero, AG; Gerovac, BJ; Han, Z; Keeler, SP; Wu, K Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof US Patent  US11407771 Publication Date 8/9/2022 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM563641
Synonyms:
2-Methoxy-N-[4-(4-{3-[5-(3- methyl-thietan-3-yl)-2-p-tolyl- 2H-pyrazol-3-yl]-ureido}- phenoxy)-pyridin-2-yl]-acetamide | US11407771, Compound 260
Type:
Small organic molecule
Emp. Form.:
C29H30N6O4S
Mol. Mass.:
558.651
SMILES:
COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C3(C)CSC3)cc2)ccn1
Structure:
Search PDB for entries with ligand similarity: