Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein [139-328]
Ligand
BDBM564861
Substrate
n/a
Meas. Tech.
Radiometric Filtration Binding Competition Assay
IC50
>100000±n/a nM
Citation
 Chamberlain, BT; Rice, JM; Jernigan, III, FE; Sherman, W; Kulkarni, MM; Shechter, S; Allen, BK; Tan, D; Marino, KA; Lin, Z Oxoacridinyl acetic acid derivatives and methods of use US Patent  US11414387 Publication Date 8/16/2022 
Target
Name:
Stimulator of interferon genes protein [139-328]
Synonyms:
Eris | Mita | Mpys | STING_MOUSE | Stimulator of interferon genes protein (STING)(139-328) | Sting | Sting1 | Tmem173
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21484.24
Organism:
Mus musculus (Mouse)
Description:
aa 139-328
Residue:
190
Sequence:
TPAEVSAVCEEKKLNVAHGLAWSYYIGYLRLILPGLQARIRMFNQLHNNMLSGAGSRRLYILFPLDCGVPDNLSVVDPNIRFRDMLPQQNIDRAGIKNRVYSNSVYEILENGQPAGVCILEYATPLQTLFAMSQDAKAGFSREDRLEQAKLFCRTLEEILEDVPESRNNCRLIVYQEPTDGNSFSLSQEV
  
Inhibitor
Name:
BDBM564861
Synonyms:
US11414387, Compound 15 | US11414387, Compound 24
Type:
Small organic molecule
Emp. Form.:
C17H15NO3
Mol. Mass.:
281.3059
SMILES:
Cc1ccc2c(c1)n(CC(O)=O)c1cc(C)ccc1c2=O
Structure:
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