Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM307573
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
>10000±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y; Skudlarek, JW Pyrrolidine orexin receptor antagonists US Patent  US10150751 Publication Date 12/11/2018 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Human
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM307573
Synonyms:
((2R,4R)-4-((4-(2,2- difluoroethoxy)pyridin-2-yl)amino)-2- methylpyrrolidin-1-yl)(2-ethoxypyridin-3- yl)methanone | US10150751, Example 6
Type:
Small organic molecule
Emp. Form.:
C20H24F2N4O3
Mol. Mass.:
406.4264
SMILES:
CCOc1ncccc1C(=O)N1C[C@@H](C[C@H]1C)Nc1cc(OCC(F)F)ccn1 |r|
Structure:
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