Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM307578
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
1086±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y; Skudlarek, JW Pyrrolidine orexin receptor antagonists US Patent  US10150751 Publication Date 12/11/2018 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM307578
Synonyms:
(2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,4R)-2- methyl-4-((4-(trifluoromethyl)pyridin-2- yl)amino)pyrrolidin-1-yl)methanone | US10150751, Example 14
Type:
Small organic molecule
Emp. Form.:
C20H19F3N6O
Mol. Mass.:
416.3997
SMILES:
C[C@@H]1C[C@H](CN1C(=O)c1ccccc1-n1nccn1)Nc1cc(ccn1)C(F)(F)F |r|
Structure:
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