Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM307596
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
66.2±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y; Skudlarek, JW Pyrrolidine orexin receptor antagonists US Patent  US10150751 Publication Date 12/11/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM307596
Synonyms:
Methyl 2-(((3R,5R)-1-(2-(2H- 1,2,3-triazol-2-yl)benzoyl)-5- methylpyrrolidin-3-yl)amino)-4- ethoxynicotinate | US10150751, Example 34
Type:
Small organic molecule
Emp. Form.:
C23H26N6O4
Mol. Mass.:
450.4903
SMILES:
CCOc1ccnc(N[C@@H]2C[C@@H](C)N(C2)C(=O)c2ccccc2-n2nccn2)c1C(=O)OC |r|
Structure:
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