Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM307606
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
278±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y; Skudlarek, JW Pyrrolidine orexin receptor antagonists US Patent  US10150751 Publication Date 12/11/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM307606
Synonyms:
((2R,4R)-4-((4-Methoxypyridin-2- yl)amino)-2-methylpyrrolidin-1-yl)(2- (3-methyl-1,2,4-oxadiazol-5- yl)phenyl)methanone | US10150751, Example 45
Type:
Small organic molecule
Emp. Form.:
C21H23N5O3
Mol. Mass.:
393.439
SMILES:
COc1cccnc1N[C@@H]1C[C@@H](C)N(C1)C(=O)c1ccccc1-c1nc(C)no1 |r|
Structure:
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