Reaction Details Report a problem with these data
Target
Vascular endothelial growth factor A
Ligand
BDBM566618
Substrate
n/a
Meas. Tech.
VEGF ELISA Assay
EC50
320±n/a nM
Citation
 Fu, J; Lou, Y; He, Y Hypoxia inducible factor-2(alpha) inhibitors and their use in the treatment of diseases US Patent  US11420936 Publication Date 8/23/2022 
Target
Name:
Vascular endothelial growth factor A
Synonyms:
VEGF | VEGF-A | VEGFA | VEGFA_HUMAN | VPF | Vascular endothelial growth factor (VEGF) | Vascular endothelial growth factor A (VEGF) | Vascular endothelial growth factor A (VEGF2) | Vascular permeability factor
Type:
Protein
Mol. Mass.:
27063.81
Organism:
Homo sapiens (Human)
Description:
P15692
Residue:
395
Sequence:
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
  
Inhibitor
Name:
BDBM566618
Synonyms:
1,3,3,4,4-pentafluoro-7-((5-fluoropyridin-3- yl)oxy)-1,2,3,4-tetrahydro-2aH- cyclopenta[cd]inden-2a-ol | US11420936, Compound 8
Type:
Small organic molecule
Emp. Form.:
C16H9F6NO2
Mol. Mass.:
361.2386
SMILES:
OC12CC(F)c3c1c(ccc3Oc1cncc(F)c1)C(F)(F)C2(F)F
Structure:
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