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Target
Toll-like receptor 8
Ligand
BDBM566790
Substrate
n/a
Meas. Tech.
TLR7/8/9 Inhibition Reporter Assays
IC50
0.600±n/a nM
Citation
 Dyckman, AJ; Mussari, CP; Haque, TS; Whiteley, BK; Posy, SL; Kumar, SR; Pasunoori, L; Hegde, S; Ramachandra Reddy, AK; Anumula, RK Aryl and heteroaryl substituted indole compounds US Patent  US11420958 Publication Date 8/23/2022 
Target
Name:
Toll-like receptor 8
Synonyms:
CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8
Type:
Enzyme
Mol. Mass.:
119828.77
Organism:
Homo sapiens (Human)
Description:
Q9NR97
Residue:
1041
Sequence:
MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYVDSIKQY
  
Inhibitor
Name:
BDBM566790
Synonyms:
US11420958, Ex. No. 159 | US11420958, Ex. No. 169 | US11420958, Ex. No. 170
Type:
Small organic molecule
Emp. Form.:
C25H29N5O
Mol. Mass.:
415.5307
SMILES:
CC(C)c1c([nH]c2ccc(cc12)-c1nnc(o1)C1CCCN(C)C1)-c1ccnc(C)c1
Structure:
Search PDB for entries with ligand similarity: