Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [179-426]
Ligand
BDBM107711
Substrate
n/a
Meas. Tech.
EGLN-1 Activity Assay
IC50
1200±n/a nM
Citation
 Kawamoto, RM; Wu, S; Evdokimov, AG; Greis, KD; Boyer, AS; Warshakoon, NC Prolyl hydroxylase inhibitors and methods of use US Patent  US11426393 Publication Date 8/30/2022 
Target
Name:
Egl nine homolog 1 [179-426]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2)
Type:
n/a
Mol. Mass.:
27759.84
Organism:
Homo sapiens (Human)
Description:
EGLN-1-179/426
Residue:
248
Sequence:
LRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM107711
Synonyms:
US11426393, Compound Table XV.17 | US8598210, Table XV, 17 | US8722895, 17: 5-(3-Chlorophenyl)-N-(2-methylamino-2- oxoethyl)-3-hydroxypyridin-2-yl amide | US9598370, Example 00142 | USRE47437, Example 5-(3-Chlorophenyl)-N-(2-methylamino-2-oxoethyl)-3-hydroxypyridin-2-yl amide
Type:
Small organic molecule
Emp. Form.:
C15H14ClN3O3
Mol. Mass.:
319.743
SMILES:
CNC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Structure:
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