Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [49-170]
Ligand
BDBM570189
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay of BRD4 Small Molecule Compounds
IC50
119±n/a nM
Citation
 Zhou, B; Luo, C; Li, Z; Yang, Y; Chen, S; Ding, H; Jiang, H; Qiao, G; Wang, X; Xiao, S Bromodomain inhibitor compound and use thereof US Patent  US11427593 Publication Date 8/30/2022 
Target
Name:
Bromodomain-containing protein 4 [49-170]
Synonyms:
BRD4 | BRD4-BD1 | BRD4-BD1 (aa 49-170) | BRD4_HUMAN | Bromodomain containing 4 (aa 49-170) | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(49-170) | Bromodomain-containing protein 4 (BRD4)(BD1) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14593.14
Organism:
Homo sapiens (Human)
Description:
aa 49-170 (BRD4-BD1)
Residue:
122
Sequence:
ETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETE
  
Inhibitor
Name:
BDBM570189
Synonyms:
US11427593, Compound ZB-BD-232
Type:
Small organic molecule
Emp. Form.:
C22H21N3O4S
Mol. Mass.:
423.485
SMILES:
Cc1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2C)n2cc[nH]c(=O)c12
Structure:
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