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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM570432
Substrate
n/a
Meas. Tech.
Enzymatic Assay
Ki
2400±n/a nM
Citation
 Bryan, MC; Drobnick, J; Kiefer, Jr., JR; Kolesnikov, A; Rajapaksa, NS Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators US Patent  US11434250 Publication Date 9/6/2022 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM570432
Synonyms:
(R)—N-(6-(3-(Hydroxymethyl)morpholino)-2,2-dimethyl-2,3-dihydrofuro[2,3-b]pyridin-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide and (S)—N-(6-(3-(Hydroxymethyl)morpholino)-2,2-dimethyl-2,3-dihydrofuro[2,3-b]pyridin-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | US11434250, Example 7 | US11434250, Example 8
Type:
Small organic molecule
Emp. Form.:
C21H26N6O4
Mol. Mass.:
426.4689
SMILES:
CC1(C)Cc2cc(NC(=O)C(\C=N)=C3/NC=CC=N3)c(nc2O1)N1CCOC[C@@H]1CO |r,c:15,17|
Structure:
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