Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM570447
Substrate
n/a
Meas. Tech.
Enzymatic Assay
Ki
9.10±n/a nM
Citation
Bryan, MC; Drobnick, J; Kiefer, Jr., JR; Kolesnikov, A; Rajapaksa, NS Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators US Patent US11434250 Publication Date 9/6/2022
More Info.:
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Inhibitor
Name:
BDBM570447
Synonyms:
N-[rac-(2S)-6-[4-(2,2- difluoroethyl)piperazin-l-yl]- 2-(hydroxymethyl)-2-methyl- 3H-furo[2,3-b]pyridin-5- yl]pyrazolo[1,5-a]pyrimidine- 3-carboxamide | US11434250, Example 20
Type:
Small organic molecule
Emp. Form.:
C22H25F2N7O3
Mol. Mass.:
473.4758
SMILES:
C[C@@]1(CO)Cc2cc(NC(=O)c3cnn4cccnc34)c(nc2O1)N1CCN(CC(F)F)CC1 |r|