Target
P2X purinoceptor 7
Ligand
BDBM510187
Substrate
n/a
Meas. Tech.
Human P2X7 Functional Assay
IC50
<50±n/a nM
Citation
 Arano, YToyoshima, KSone, TMatsubara, K Tetrahydroquinoline derivatives as P2X7 receptor antagonists US Patent  US11439633 Publication Date 9/13/2022 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM510187
Synonyms:
N-(2,4-dichloro- 6-meth- ylbenzyl)-8-((dimeth- ylamino)meth- yl)-5-fluoro-8- hydroxy-5,6,7,8- tetrahydroquinoline- 5-carboxamide | US11077100, Example 47 | US11439633, Example 47
Type:
Small organic molecule
Emp. Form.:
C21H24Cl2FN3O2
Mol. Mass.:
440.339
SMILES:
CN(C)CC1(O)CCC(F)(C(=O)NCc2c(C)cc(Cl)cc2Cl)c2cccnc12
Structure:
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