Reaction Details Report a problem with these data
Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM571321
Substrate
n/a
Meas. Tech.
RIPK1 HTRF Binding Assay
IC50
1.000±n/a nM
Citation
 Mertzman, ME; Dzierba, CD; Guernon, JM; Hart, AC; Luo, G; Macor, JE; Pitts, WJ; Shi, J; Spergel, SH Aminoimidazopyridazines as kinase inhibitors US Patent  US11440913 Publication Date 9/13/2022 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75926.99
Organism:
Homo sapiens (Human)
Description:
Q13546
Residue:
671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
  
Inhibitor
Name:
BDBM571321
Synonyms:
(R)-5-(2- acetamidoimidazo [1,2-b]pyridazin- 6-yl)-N-(1- (2-fluoro-5- (trifluoromethoxy) phenyl)ethyl)-2- methylbenzamide | US11440913, Example 396
Type:
Small organic molecule
Emp. Form.:
C25H21F4N5O3
Mol. Mass.:
515.4596
SMILES:
C[C@@H](NC(=O)c1cc(ccc1C)-c1ccc2nc(NC(C)=O)cn2n1)c1cc(OC(F)(F)F)ccc1F |r|
Structure:
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