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Target
Isoform APP695 of Amyloid-beta precursor protein [K595N,M596L]
Ligand
BDBM50502720
Substrate
n/a
Meas. Tech.
Cellular gamma-Secretase Assay
EC50
31.0±n/a nM
Citation
 Bartels, B; Cook, XA; Ratni, H; Reutlinger, M; Vifian, W Triazolo-azepine derivatives US Patent  US11440915 Publication Date 9/13/2022 
Target
Name:
Isoform APP695 of Amyloid-beta precursor protein [K595N,M596L]
Synonyms:
A4 | A4_HUMAN | AD1 | APP | Amyloid-beta precursor protein | Amyloid-beta precursor protein (PreA4 695) [K595N,M596L] | Isoform APP695 (K595N,M596L)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
78580.06
Organism:
Homo sapiens (Human)
Description:
P05067-4(K595N,M596L)
Residue:
695
Sequence:
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVNLDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
  
Inhibitor
Name:
BDBM50502720
Synonyms:
CHEMBL4474921 | US11440915, Example 4
Type:
Small organic molecule
Emp. Form.:
C22H25FN6
Mol. Mass.:
392.4725
SMILES:
Cc1cn(cn1)C12CC(C1)(C2)Nc1nc2[C@@H](CCCCn2n1)c1ccc(F)cc1 |r|
Structure:
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