Reaction Details
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Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide
Ligand
BDBM571514
Substrate
n/a
Meas. Tech.
Protein-Protein Interaction Assay: MCL-1/Noxa BH3 Peptide (MCL-1 Assay)
IC50
0.420±n/a nM
Citation
Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Mönning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA Substituted macrocyclic indole derivatives US Patent US11440923 Publication Date 9/13/2022 More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide
Synonyms:
MCL-1/Noxa BH3 Peptide
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 3 components.
Component 1
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]
Synonyms:
BCL2L3 | MCL1 | MCL1_HUMAN
Type:
n/a
Mol. Mass.:
17056.39
Organism:
Homo sapiens (Human)
Description:
Q07820[173-321]
Residue:
149
Sequence:
ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
Component 2
Name:
Maltose/maltodextrin import ATP-binding protein MalK
Synonyms:
MALK_ECOLI | malK
Type:
Protein
Mol. Mass.:
40990.98
Organism:
n/a
Description:
P68187
Residue:
371
Sequence:
MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV
Component 3
Name:
Phorbol-12-myristate-13-acetate-induced protein 1 [17-23,25-42,C24V]
Synonyms:
APR_HUMAN | Immediate-early-response protein APR | NOXA | PMA-induced protein 1 | PMAIP1 | Protein Noxa
Type:
Protein
Mol. Mass.:
3072.54
Organism:
Human
Description:
Biotin-PEG2-PEG2-PAELEVE-Nva-ATQLRRFGDKLNFRQKLL-amide
Residue:
26
Sequence:
PAELEVEVATQLRRFGDKLNFRQKLL
Inhibitor
Name:
BDBM571514
Synonyms:
(+)-4-chloro-15-[2-(3,3-difluoroazetidin-1-yl)ethyl]-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 1) | US11440923, Example 78
Type:
Small organic molecule
Emp. Form.:
C38H40ClF3N4O4
Mol. Mass.:
709.197
SMILES:
CCc1c-2c(nn1C)C(CCN1CC(F)(F)C1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13
Structure:
