Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM571878
Substrate
n/a
Meas. Tech.
Binding Inhibition for Dopamine D3 Receptor
Ki
0.240±n/a nM
Citation
 Ichihashi, Y; Inagaki, M; Masuda, K Cyclic compound having dopamine D3 receptor antagonistic effect US Patent  US11447484 Publication Date 9/20/2022 
Target
Name:
D(3) dopamine receptor
Synonyms:
DRD3 | DRD3_HUMAN | Dopamine D3 receptor
Type:
PROTEIN
Mol. Mass.:
44213.40
Organism:
Homo sapiens
Description:
ChEMBL_105671
Residue:
400
Sequence:
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM571878
Synonyms:
US11447484, Compound I-035
Type:
Small organic molecule
Emp. Form.:
C26H32F2N6O2
Mol. Mass.:
498.5681
SMILES:
Cn1cc2c(cccc2n1)C(=O)NN1CCC(CCN2C[C@@H]3C[C@@]3(C2)c2cc(on2)C(C)(F)F)CC1 |r|
Structure:
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