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Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM572864
Substrate
n/a
Meas. Tech.
Enzyme Assay and NMN Detection
EC50
<100±n/a nM
Citation
 Gardell, S; Pinkerton, AB; Sergienko, E; Sessions, H Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof US Patent  US11452717 Publication Date 9/27/2022 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM572864
Synonyms:
1-((1H-Pyrazol-4-yl)methyl)-3-(4-((3-(trifluoromethyl)phenyl)sulfonyl)phenyl)urea | US11452717, Compound TableB-4.7 | US11452717, Compound TableB-6.30
Type:
Small organic molecule
Emp. Form.:
C18H15F3N4O3S
Mol. Mass.:
424.397
SMILES:
FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(NC(=O)NCc2cn[nH]c2)cc1
Structure:
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