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Target
Polymerase acidic protein
Ligand
BDBM474341
Substrate
n/a
Meas. Tech.
Endonuclease Inhibition Assay
IC50
70.0±n/a nM
Citation
 Jain, R; Koester, DC; Manning, JR; Sutton, JC; Taft, BR; Wan, L; Zhao, Q Tricyclic compounds useful to treat orthomyxovirus infections US Patent  US11453677 Publication Date 9/27/2022 
Target
Name:
Polymerase acidic protein
Synonyms:
PA | PA_I75A3 | RNA-directed RNA polymerase subunit P2
Type:
Protein
Mol. Mass.:
82806.72
Organism:
n/a
Description:
P31343
Residue:
716
Sequence:
MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEGMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGCIEGKLSQMSKEVNAKIEPFLKTTPRPIKLPDGPPCFQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPYIVKPHERGINSNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGENMAPEKVDFDNCRDISDLKQYDSDEPELRSLSSWIQNEFNKACELTDSIWIELDEIGEDVAPIEYIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSAIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLVVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
 
Inhibitor
Name:
BDBM474341
Synonyms:
6-(bis(3-fluorophenyl)methyl)-11-hydroxy- 5,6-dihydro-10H- imidazo[2',1':3,4]pyrazino[1,2-b]pyridazin-10- one | US10858366, Example 2 | US11453677, Example 2
Type:
Small organic molecule
Emp. Form.:
C22H16F2N4O2
Mol. Mass.:
406.3848
SMILES:
Oc1c2-c3nccn3CC(C(c3cccc(F)c3)c3cccc(F)c3)n2ncc1=O
Structure:
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