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Target
Polymerase acidic protein
Ligand
BDBM474342
Substrate
n/a
Meas. Tech.
Endonuclease Inhibition Assay
IC50
400±n/a nM
Citation
 Jain, R; Koester, DC; Manning, JR; Sutton, JC; Taft, BR; Wan, L; Zhao, Q Tricyclic compounds useful to treat orthomyxovirus infections US Patent  US11453677 Publication Date 9/27/2022 
Target
Name:
Polymerase acidic protein
Synonyms:
PA | PA_I75A3 | RNA-directed RNA polymerase subunit P2
Type:
Protein
Mol. Mass.:
82806.72
Organism:
n/a
Description:
P31343
Residue:
716
Sequence:
MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEGMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGCIEGKLSQMSKEVNAKIEPFLKTTPRPIKLPDGPPCFQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPYIVKPHERGINSNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGENMAPEKVDFDNCRDISDLKQYDSDEPELRSLSSWIQNEFNKACELTDSIWIELDEIGEDVAPIEYIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSAIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLVVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
 
Inhibitor
Name:
BDBM474342
Synonyms:
6-benzhydryl-11-hydroxy-5,6-dihydro-10H- [1,2,4]triazolo[5',1':3,4]pyrazino[1,2- b]pyridazin-10-one | US10858366, Example 3 | US11453677, Example 3
Type:
Small organic molecule
Emp. Form.:
C21H17N5O2
Mol. Mass.:
371.392
SMILES:
Oc1c2-c3ncnn3CC(C(c3ccccc3)c3ccccc3)n2ncc1=O
Structure:
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